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Aptamer Technologies


Imaging probes
Purification, cell sorting, sandwich assays
Therapeutic agents
Target validation, drug delivery and drug discovery

Sectors of activity

Health & Biology
Food & Nutrition
Chemistry & Pharmaceuticals

Aptamers are single-stranded structured nucleic acids (DNA, RNA or modified RNA) selected from a random oligonucleotide library against a predetermined target, through a combinatorial strategy named SELEX (Systematic Evolution of Ligands by EXponential enrichment). Aptamers can be selected against any type of target: proteins, peptides, nucleic acids, small molecules, toxins, cells, viruses. They bind to their target with high affinity and specificity as they adopt tridimensional structures. Aptamers present many advantages: easy chemical synthesis once selected; storage conditions; chemical modifications are also easily introduced within the sequence or at either end. These properties make them relevant alternatives to monoclonal antibodies as diagnostic, analytical or therapeutic agents.

The SELEX method is a powerful strategy but time consuming with iterative steps of selection and amplification. Two platforms, unique in France, have been assembled in the Dr. Toulmé’s lab to perform automated selection and production of aptamers.

The automation of the procedure has led to the development of a biotechnological activity in the field of aptamer innovation and technology transfer. These know-how and expertise, after 25 years of academic research, have been transferred to Novaptech.